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Sumter County Parks and Recreation gymnasts compete in ...
On the weekend of February 24-26, the gymnastics team from Sumter County Gymnastics Academy traveled to Sevierville, TN to compete in the Smoky Mountain Gymnastics Vacation Classic. There were over 1300 gymnasts represented from 30 or more gymnastics schools across the south east.
Read more here:
Sumter County Parks and Recreation gymnasts compete in Sevierville
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Graduate Student Loan Calculator
Tuesday, March 6th, 2012 at 6:02 am ?
Constructing Graduate Student Budgets
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Study shows advance in using patients' own tumor-fighting cells to knock back advanced melanoma
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Public release date: 5-Mar-2012[ | E-mail |
Share ] Contact: Dean Forbes
dforbes@fhcrc.org
206-667-2896
Fred Hutchinson Cancer Research Center
SEATTLE A small, early-phase clinical trial to test the effectiveness of treating patients with advanced melanoma using billions of clones of their own tumor-fighting cells combined with a specific type of chemotherapy has shown that the approach has promise. One patient of the 11 experienced a long-term, complete remission that has lasted more than three years, and in four others with progressive disease, the melanoma temporarily stopped growing. The results of the study are published in the Early Edition of the Proceedings of the National Academy of Sciences for the week of March 5.
The goal of the research, led by Cassian Yee, M.D., a member of the Clinical Research Divison of Fred Hutchinson Cancer Research Center, was to find the optimum cellular environment in which to infuse 15 billion to 20 billion cancer-fighting CD8+ T cells so that they persisted for as long as possible in the body to battle the tumors. The cells, which were extracted from the patients and multiplied in the lab before re-infusion, are a type of white blood cell that attacks a protein associated with the cancer.
All of the patients in this study had progressive metastatic melanoma that no longer responded to traditional therapy. Prior to the T-cell infusions, all were treated with high doses of cyclophosphamide to eradicate their lymphocytes, a type of white blood cell that is part of the immune system. This was done to stimulate the production of certain growth factors that help promote further expansion of the T cells within the body.
Eight of the 11 patients received low doses of interleukin-2 growth factor after the T cells were infused to further promote cell growth. Among these patients, one showed a complete remission and four patients, who had failed conventional therapy, experienced a temporary non-progression of their disease. The remaining three patients received higher doses of IL-2, which was found to be more toxic to the body. Two of these patients had temporary non-progression of their disease.
In all of the patients, except for the one who attained a complete remission, their disease eventually progressed within 12 to 19 weeks of T-cell infusion.
Individual variations between patients with regard to how long the infused T cells persisted within the body probably accounted for why some responded to treatment better than others. "Certainly there are differences between patients but we think that persistence of the infused T cells in the body has a lot to do with it," Yee said. "It tells us we certainly have a way to go."
Yee said the study has two key findings that point toward the optimum environment in which to use adoptively transferred tumor-specific T cells:
- The use of high-dose cyclophosphamide alone is a safe inpatient procedure and resulted in the T cells persisting much longer in the body compared to regiments used in previous studies that used different chemotherapy drugs or none at all. What was novel in this trial, according to Yee, was that high-dose cyclophosphamide alone was enough. Other studies have routinely used a combination of cyclophosphamide with fludarabine and/or radiation therapy to deplete lymphocytes, followed by high-dose IL-2, which is a far more toxic regimen for patients who often require intensive care management during therapy. So-called lymphodepletion is important for engraftment of the infused cells so that the body produces IL-7 and IL-15 growth factors while rebuilding the lymphocyte population to normal levels. Low-dose IL-2 given on an outpatient basis following the cell infusions was found to be nontoxic.
- The CD8+ T-cell clones infused into the patients are long lasting and, the researchers theorize, are derived from central memory T cells, which can fight cancer and infections. "When we infused them as clones, they reverted back to an earlier memory type of T cell," Yee said. "This is important because these cell types have a high potential to proliferate in the patient."
In two of the patients the researchers found upregulation of the IL-7 growth factor receptor and CD28 levels both of which are important for giving the T cells a growth advantage. A protein encoded by the CD28 gene is essential for T-cell proliferation and survival. The cloned cells showed the potential to become "help independent" from the need to use other growth agents.
"Our results confirm that if we can develop methods to grow these kinds of cells in the lab, then we can give these high-proliferating, helper-independent T cells to all patients for T-cell therapy," said Yee, who is a researcher in the Hutchinson Center's immunotherapy program. "Fortunately, we have been able to achieve this goal and are in the process of treating patients in an ongoing study with these helper-independent T cells."
Future studies may use different variants of interleukin growth factor and perhaps even vaccines to boost the body's response to the infused cells, he said.
###
Colleagues from Seattle Cancer Care Alliance and the University of Washington collaborated on the study. Grants from the National Institutes of Health and the National Cancer Institute supported the research. Yee also is supported by a Clincal Scientist Award in Translational Research from the Burroughs Wellcome Fund.
At Fred Hutchinson Cancer Research Center, our interdisciplinary teams of world-renowned scientists and humanitarians work together to prevent, diagnose and treat cancer, HIV/AIDS and other diseases. Our researchers, including three Nobel laureates, bring a relentless pursuit and passion for health, knowledge and hope to their work and to the world. For more information, please visit fhcrc.org.
CONTACT
Dean Forbes
206-667-2896
dforbes@fhcrc.org
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Public release date: 5-Mar-2012[ | E-mail |
Share ] Contact: Dean Forbes
dforbes@fhcrc.org
206-667-2896
Fred Hutchinson Cancer Research Center
SEATTLE A small, early-phase clinical trial to test the effectiveness of treating patients with advanced melanoma using billions of clones of their own tumor-fighting cells combined with a specific type of chemotherapy has shown that the approach has promise. One patient of the 11 experienced a long-term, complete remission that has lasted more than three years, and in four others with progressive disease, the melanoma temporarily stopped growing. The results of the study are published in the Early Edition of the Proceedings of the National Academy of Sciences for the week of March 5.
The goal of the research, led by Cassian Yee, M.D., a member of the Clinical Research Divison of Fred Hutchinson Cancer Research Center, was to find the optimum cellular environment in which to infuse 15 billion to 20 billion cancer-fighting CD8+ T cells so that they persisted for as long as possible in the body to battle the tumors. The cells, which were extracted from the patients and multiplied in the lab before re-infusion, are a type of white blood cell that attacks a protein associated with the cancer.
All of the patients in this study had progressive metastatic melanoma that no longer responded to traditional therapy. Prior to the T-cell infusions, all were treated with high doses of cyclophosphamide to eradicate their lymphocytes, a type of white blood cell that is part of the immune system. This was done to stimulate the production of certain growth factors that help promote further expansion of the T cells within the body.
Eight of the 11 patients received low doses of interleukin-2 growth factor after the T cells were infused to further promote cell growth. Among these patients, one showed a complete remission and four patients, who had failed conventional therapy, experienced a temporary non-progression of their disease. The remaining three patients received higher doses of IL-2, which was found to be more toxic to the body. Two of these patients had temporary non-progression of their disease.
In all of the patients, except for the one who attained a complete remission, their disease eventually progressed within 12 to 19 weeks of T-cell infusion.
Individual variations between patients with regard to how long the infused T cells persisted within the body probably accounted for why some responded to treatment better than others. "Certainly there are differences between patients but we think that persistence of the infused T cells in the body has a lot to do with it," Yee said. "It tells us we certainly have a way to go."
Yee said the study has two key findings that point toward the optimum environment in which to use adoptively transferred tumor-specific T cells:
- The use of high-dose cyclophosphamide alone is a safe inpatient procedure and resulted in the T cells persisting much longer in the body compared to regiments used in previous studies that used different chemotherapy drugs or none at all. What was novel in this trial, according to Yee, was that high-dose cyclophosphamide alone was enough. Other studies have routinely used a combination of cyclophosphamide with fludarabine and/or radiation therapy to deplete lymphocytes, followed by high-dose IL-2, which is a far more toxic regimen for patients who often require intensive care management during therapy. So-called lymphodepletion is important for engraftment of the infused cells so that the body produces IL-7 and IL-15 growth factors while rebuilding the lymphocyte population to normal levels. Low-dose IL-2 given on an outpatient basis following the cell infusions was found to be nontoxic.
- The CD8+ T-cell clones infused into the patients are long lasting and, the researchers theorize, are derived from central memory T cells, which can fight cancer and infections. "When we infused them as clones, they reverted back to an earlier memory type of T cell," Yee said. "This is important because these cell types have a high potential to proliferate in the patient."
In two of the patients the researchers found upregulation of the IL-7 growth factor receptor and CD28 levels both of which are important for giving the T cells a growth advantage. A protein encoded by the CD28 gene is essential for T-cell proliferation and survival. The cloned cells showed the potential to become "help independent" from the need to use other growth agents.
"Our results confirm that if we can develop methods to grow these kinds of cells in the lab, then we can give these high-proliferating, helper-independent T cells to all patients for T-cell therapy," said Yee, who is a researcher in the Hutchinson Center's immunotherapy program. "Fortunately, we have been able to achieve this goal and are in the process of treating patients in an ongoing study with these helper-independent T cells."
Future studies may use different variants of interleukin growth factor and perhaps even vaccines to boost the body's response to the infused cells, he said.
###
Colleagues from Seattle Cancer Care Alliance and the University of Washington collaborated on the study. Grants from the National Institutes of Health and the National Cancer Institute supported the research. Yee also is supported by a Clincal Scientist Award in Translational Research from the Burroughs Wellcome Fund.
At Fred Hutchinson Cancer Research Center, our interdisciplinary teams of world-renowned scientists and humanitarians work together to prevent, diagnose and treat cancer, HIV/AIDS and other diseases. Our researchers, including three Nobel laureates, bring a relentless pursuit and passion for health, knowledge and hope to their work and to the world. For more information, please visit fhcrc.org.
CONTACT
Dean Forbes
206-667-2896
dforbes@fhcrc.org
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Source: http://www.eurekalert.org/pub_releases/2012-03/fhcr-ssa022912.php
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Video: 'The Hansen Files': Drug Trials, Part 4
Dateline NBC
'Dateline NBC,' the signature broadcast for NBC News in primetime, premiered in 1992. Since then, it has been pioneering a new approach to primetime news programming. The multi-night franchise, supplemented by frequent specials, allows NBC to consistently and comprehensively present the highest-quality reporting, investigative features, breaking news coverage and newsmaker profiles.
Source: http://www.msnbc.msn.com/id/3032600/vp/46615550#46615550
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Pregnant state and funds ? Fund Needs To get Specialist ... - Home 2
Quite a few expert women worry the prospect of getting pregnant because of fiscal challenges. It isn?t unusual nowadays to locate girls who are the largest earnings earners within their house which in turn begs the particular dilemma: how can you afford to employ a newborn and maintain your own self? The response to this inquiry depends on your individual scenarios, having said that regardless of what individuals scenarios will be, how?s that for a location that can be worked well by way of when you are happy to invest some time planning ahead in your pregnancy in addition to beyond.
For the people money professionals in existence, My spouse and i promote anyone to avoid the impulse to leap ahead of time and make your hair a lower cash flow style in relation to pregnancy! Just before we jump to specific financial records, usually there are some essential concerns you will need to consider:
One. What pregnancy-related fees contemplating right up pertaining to? There may be described as a quantity of meetings you will want to be present at with various doctors this sort of pertaining to ultra-sounds together with phased check-ups using your physician. The expenses of such professional medical sessions vary for every single professional and also will rely on no matter whether you want to allow labor and birth inside of a open public as well as non-public medical. You may even want to consider the possible valuation on In vitro fertilization treatments (in-vitro fertilization) services.
3. What goods will you be needing to get in your newborn? The best place first of all this inquiry is usually to request alternative first-time moms relating to activities. An array of frequent necessities include things like:
Little one parcels
Shower merchandise
Containers
Bibs
Modify family table
Attire
Cot
Diapers
Stooge
Diaper ointment
Pram
Little one retailers may also present you with plenty of strategies however it might help to formulate your personal active check-it-out in addition to approx . price range prior to severe back pain during pregnancy spend your life personal savings in newborn merchandise! For more budget-conscious women, it can absolutely assist with likely be operational oriented in relation to utilizing pre-loved items which best freinds and family may well pass around back.
Three or more. The span of time do you plan to be at home? Although some of you may well enjoy the thinking behind residing at property in your baby?s newbie, alternative expert women might be irritation for getting into the labor force. Whichever your preference, it is advisable to establish a plan for residing at property as well as okay perform. You may want to think about the right after:
Just how much compensated in addition to unsettled maternity abandon can your business supply?
Are you going to your wages derive from while having a day off?
May fiscal help be around from a wife or husband as well as associate?
Really does your company supply variable doing the job preparations (part-time, job reveal)
Do you possess some other sources of earnings outside your career? Some examples occasionally includes earnings on the selling of possessions as well as shares or even pulling on your home property finance loan. You can even choose to investigate methods of producing cash from your own home.
Since you have coated off of in some of the money fundamentals in planning pertaining to pregnancy, you?re ready take out your piece of paper in addition to calculator or your Exceed spread sheet. You will want to start 2 variations of this house price range:
Model One: your present house price range such as many sources of earnings and also your present-day expenditures.
Version 5: a prolonged edition of this house price range of which excludes the particular earnings through your job in addition to incorporates your brand-new baby-related expenditures.
It is best to set up your financial allowance by thirty days over the 12 months stop snoring period. That way, you will be able to capture expenditures of which happen in a definite thirty days of year, just like many insurance costs and you should likewise be able to see the volume of many weeks you can afford to be home more.
If you desire to carry this further in addition to a small amount of fiscal which knowledge within your harness, you will want to develop your personal pregnancy cash flow style to compare the outcome of various stay-at-home as well as return-to-work circumstances? Discover a numbers man or women, you will want to request a coworker to assist you as well as help make a session to talk to your accountancy firm and enquire them to run the particular circumstances for yourself.
Possessing a robust price range can guide you to plan for the particular fiscal component of your pregnancy and can lower back arthritis furthermore assist you to handle your current house financial circumstances. As you now have learned to get your financial circumstances in order during your pregnancy, you may direct your attention in getting pregnant in addition to taking on maternity as it?s certain to often be probably the most worthwhile steps you have ever had.
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Interpreting Riding Breeches | Articles Fancy
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