মঙ্গলবার, ৩ এপ্রিল, ২০১২

Newcastle United Liverpool live stream free 2011 Barclays Premier ...

When taking a look at Newcastle U . s . home efficiency in group points, Newcastle United?s overall performance is best when investigating opponents inside bottom 6 with typically 2. 38 points per video game.

Against opponent like Liverpool that may be currently used in the middle 8 of the English Most recognized League Newcastle Usa has were able to collect typically 1. 6 details in 5 matches this season. Concerning meets played in the home against your mid 8 there is much surprise Newcastle U . s . has obtained 1. 67 points on average in 3 fits.

When taking a look at Liverpool absent performance within league factors, Liverpool?s efficiency is very best when investigating opponents inside the mid 8 with typically 1. 5 factors per game.

Against opponent like Newcastle United that is currently put in the major 6 with the Australia Any League Gatwick has was able to collect an average of 1. 2 things in 10 matches this season. When looking at matches played out away up against the top 6 this season Liverpool features collected 1. 2 points on average in 5 suits.

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    সোমবার, ২ এপ্রিল, ২০১২

    Report: Brain cancer blood vessels not substantially tumor-derived ...

    April 2, 2012Print version

    Johns Hopkins scientists have published laboratory data refuting studies that suggest blood vessels that form within brain cancers are largely made up of cancer cells. The theory of cancer-based blood vessels calls into question the use and value of anti-cancer drugs that target these blood vessels, including bevacizumab (Avastin).

    ?We don?t question whether brain cancer cells have the potential to express blood vessel markers and may occasionally find their way into blood vessels, but we do question the extent to which this happens,? said Charles Eberhart, chief of Neuropathology at the Johns Hopkins University School of Medicine. ?In general, we find no evidence in our study that these vessels contain substantial amounts of cancer cells.?

    Eberhart, a professor of pathology, ophthalmology and oncology, said that he first encountered claims about the cancerous nature of tumor blood vessels about a year ago, when he was invited to join students at a journal club meeting, a forum for discussing studies published in medical journals. ?My first reaction to this research was, ?How could this be true??? Eberhart said. ?Our clinical experience examining tissue from brain cancers does not support it.?

    Studies have long demonstrated that malignant brain tumors contain large numbers of blood vessels to feed their growing demand for nutrients. The blood vessels are formed when tumors pump out growth factors that increase vessel production. Such studies opened the door to treatment strategies that specifically targeted blood-vessel growth and the vessel cells themselves.

    More recently, scientists in Italy and at the Memorial Sloan-Kettering Cancer Center in New York published results of studies suggesting that these tumor blood vessels are made by primitive types of brain cancer cells that are a form of stem cells. In their studies, they found tumor markers on blood vessel cells in 20 to 90 percent of their brain cancer samples. The research teams said that their findings also suggested that the cancerlike blood vessels were more prone to drug resistance, potentially explaining why drugs such as bevacizumab yield tumor-shrinking responses, but only for short periods. Bevacizumab is currently approved by the Food and Drug Administration for use in patients with colorectal, lung, kidney and brain cancers.

    Eberhart said that pathologists, including those who work on brain tissue, use certain tissue-based techniques to distinguish cancer cells from normal ones. When evaluating specimens of brain tissue removed during surgery for suspected cancer, he said, most pathologists agree that blood vessel cells in these specimens consistently lack the molecular changes associated with cancer cells. In fact, he said, the pathologists often use these blood vessel cells as ?normal controls? to compare with potentially cancerous ones.

    After the journal club experience, Eberhart teamed up with fellow Johns Hopkins neuropathologist Fausto Rodriguez and colleagues at the Dana-Farber Cancer Institute and Harvard Medical School in Boston to look more closely at the molecular features of blood vessel cells in brain cancer samples. They tested more than 100 samples from patients at Johns Hopkins and Dana-Farber for EGFR and IDH1 markers, two common genes altered in brain cancer.

    ?We also used a marker called CD34 to differentiate vascular [blood vessel] cells from other types of cells,? said Rodriguez, an assistant professor of pathology. The researchers found no more than 10 percent of their samples contained vascular cells with EGFR or IDH1 cancer markers, and in those rare tumor samples, only a few cells exhibited those markers. The team tested all parts of the vessel walls for presence of the cancer markers.

    Results of the team?s laboratory experiments were published in the online journal Oncotarget in January.

    Although the two groups used different markers to identify vessel cells, Rodriguez said that ?there is no marker that is absolute for each cell.?

    Eberhart and Rodriguez noted that the U.S./Italian research teams focused mainly on cell-by-cell research techniques in dissociated specimens to evaluate cancer markers, losing associations that can be made by looking at a cell?s shape and physical relationship within clusters of cells. The Johns Hopkins and Dana-Farber researchers conducted studies examining cells in intact tissue.

    ?Pathologists with extensive experience in examining cells become accustomed to quickly identifying a blood vessel cell from a normal cell, and we can gain a lot of information when we look at how cells connect with other cells in real-life examples,? noted Rodriguez, who said that his team?s findings could potentially apply to any cancer thought to contain stem cells.

    In addition to Eberhart and Rodriguez, the research team included Brent Orr, of Johns Hopkins; and Keith Ligon, of the Dana-Farber Cancer Institute and Harvard Medical School.

    Funding for the study was provided by a National Institutes of Health postdoctoral fellowship to Orr and a grant to Eberhart.

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    Related website

    ?Oncotarget?

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    রবিবার, ১ এপ্রিল, ২০১২

    Atari Pong review (1976)

    Atari Pong review
    Multiplayer gaming today has become an inherently and bewilderingly antisocial affair. You grab a controller, take up as much space as possible on your couch at home, then connect to some random game hosted by some random server filled with some random people with whom you do your damnedest to fill with some collection of lead thrown from some assortment of futuristic weaponry. Along the way, you'll be taunted, insulted and, if you're playing a Halo game, quite possibly physically shamed.

    Back in 1976, of course, things were a bit different. Pong was the height of at-home multiplayer gaming. Two dials, one button and one switch is all you had, and with your opponent sitting in extremely close proximity to you, chances are most of the heckling would be the good-natured variety. It is a vastly simplified experience versus what we have today, but in some ways a vastly superior one. Click on through to see why.

    Continue reading Atari Pong review (1976)

    Atari Pong review (1976) originally appeared on Engadget on Sun, 01 Apr 2012 12:19:00 EDT. Please see our terms for use of feeds.

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    timesofindia: India sends special envoy to South Sudan to tap energy resources http://t.co/fehhoyQG

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    Falklands row could hit UK's S.American ambitions

    LONDON (Reuters) - Thirty years after Britain and Argentina went to war over the Falklands, relations are at their chilliest in years as Buenos Aires launches a multi-pronged diplomatic offensive to assert its claim to sovereignty over the South Atlantic islands.

    While a new military conflict is seen as highly unlikely, the dispute could jeopardise Britain's drive for closer economic and trade ties with emerging Latin America powers such as Brazil that it hopes will kickstart the stagnating British economy.

    The discovery of oil off the Falklands has raised the stakes, leading Argentina to threaten to sue companies involved in oil exploration and to protest to the United Nations over British "militarisation" of the South Atlantic.

    On Sunday, the eve of the 30th anniversary of the start of the Falklands War, the Sunday Telegraph said Argentina had threatened legal action against British and U.S. banks that gave advice to or even wrote research reports about companies involved in the Falklands oil sector.

    Buenos Aires has won support from regional bodies, and the Latin American trading bloc Mercosur has banned port visits by Falklands-flagged ships.

    Argentine President Cristina Fernandez and British Prime Minister David Cameron have traded accusations of "colonialism".

    Argentina wants to renegotiate a 1999 accord that allows a weekly flight to the Falklands by Chilean airline Lan, proposing that state-run Aerolineas Argentinas should fly to the remote islands, some 300 miles (480 kms) off Argentina, instead.

    The islanders are sceptical, saying the change would increase Argentina's control over access to the Falklands.

    London has controlled the islands since 1833. Argentina has claimed the territory - which it calls the Malvinas - since that date, saying it inherited it from Spain on independence and that Britain expelled an Argentine population from the islands.

    Argentina wants Britain to negotiate on sovereignty, but London refuses to do so unless the staunchly pro-British islanders ask for talks - which they show no sign of doing. Britain accuses Buenos Aires of trying to impose an economic blockade on the 3,000 islanders.

    "We do take very seriously what has now become a sustained and intense and sometimes quite aggressive diplomatic campaign by Argentina which has intensified over the last four or five months," a British diplomatic source said.

    The Argentine government assumes "that if they push hard enough and make enough noise, they will somehow bring us back to the negotiating table, (and) we will sit down and start talking about sovereignty, which isn't going to happen, "the source said.

    Argentina is clearly trying to regionalise the issue, "to make this into a disagreement between Latin America and Britain as opposed to just between Argentina and Britain," the source added.

    TEN WEEKS OF WAR

    Argentina's ruling military junta invaded the Falklands on April 2, 1982. Britain sent a naval task force and recaptured the islands after a 10-week war, with the loss of 255 British and 650 Argentine lives.

    Diplomatic relations were restored by Argentine President Carlos Menem in 1990 and ties improved - only to cool once more when Nestor Kirchner, Fernandez's late husband and predecessor as president, took office in 2003.

    They have since deteriorated further, though Britain remains an important investor and trading partner of Argentina.

    Klaus Dodds, professor of geopolitics at London University's Royal Holloway college, said bilateral ties were probably in their worst state since 1982. "The UK government is having to spend more and more time and resources in rebutting Argentine accusations," he told Reuters.

    The discovery of offshore oil has fuelled the row.

    Fernandez, a centre-leftist who hails from the chilly Patagonian region closest to the Falklands, has condemned "the plundering of our natural resources, our oil."

    Rockhopper Exploration Plc estimates there are 350 million barrels of recoverable oil at its Sea Lion discovery off the Falklands and plans to start pumping oil by 2016. If four other wells come in as hoped, Edison Investment Research says the tax and royalty windfall could reach $167 billion.

    Argentina's threat of legal action against firms exploring for oil off the Falklands could make them think twice before getting involved - or at least push up the cost of extracting the oil.

    In a sign of regional support for Argentina, the UNASUR group of South American nations rejected British oil exploration around the Falklands in March, and Peru cancelled a visit by a Royal Navy frigate.

    BRITAIN WANTS MORE TRADE

    Latin American backing for Argentina could also deal a blow to British hopes of expanding trade with the continent.

    The Conservative-Liberal Democrat coalition in power in London since 2010 says it wants a new chapter in relations with Latin America as part of its drive to increase trade and investment links with fast-growing emerging markets.

    Andrew Rosindell, a Conservative legislator and secretary of an all-party parliamentary group on the Falklands, said part of Argentina's strategy was to force Britain to choose between loyalty to the Falklands and ties with Latin America.

    "It's not going to work because what they've got to understand is that when it comes to defending your own people, your own people will always come first, before trade links," he told Reuters.

    British diplomats say Latin American gestures of support for Argentina are often symbolic and have had little practical impact so far.

    Foreign Secretary William Hague, visiting Brazil in January, said Britain was increasing its diplomatic staff across Latin America, opening several new diplomatic missions and stepping up ministerial visits.

    British exports to Brazil rose nine percent in 2011 after a 23 percent jump in 2010, and Britain had set a goal of doubling trade with Brazil, Mexico and Colombia by 2015, he said.

    Jeremy Browne, Foreign Office minister for Latin America, told Reuters in January the Falklands came up in conversation with his Latin American counterparts, "but I don't think it is a barrier to stronger working relations with countries in Latin America, with the exception of Argentina."

    Rosindell and Derek Twigg, an opposition Labour lawmaker who chairs the all-party group on the Falklands, both said there was strong support across the British political spectrum for the Falkland Islanders' right to self-determination and, with memories of the war still fresh, they did not believe any British government could negotiate sovereignty with Argentina.

    "Any party, whether Labour or Liberal Democrats or Tories (Conservatives), are very clear: Self-determination is the absolute key. There is no budging from that point," Twigg told Reuters.

    DIPLOMATIC OFFENSIVE

    British officials are ready for Argentina's diplomatic offensive to continue for at least the next few months while the war anniversary keeps the Falklands in the media spotlight.

    Argentine Industry Minister Debora Giorgi drew British protests in February by urging business leaders to replace British imports with products from countries that respect Argentina's claim to sovereignty over the Falklands.

    Britain asked the European Union, which represents EU member states in trade matters, to intervene with Argentina, and has responded to the Argentine diplomatic offensive by doing more to explain its position on the Falklands to Latin American nations.

    "We are trying to keep the level of the rhetoric and the excitement around this issue at a sensible level and emphasizing to the region we are not trying to escalate it," the British diplomatic source said.

    Rosindell said Britain should make its case more forcefully. "I think we've been too laid back on a diplomatic level. We need to do a lot more. We need to start speaking up more loudly. We need to ensure countries around the world understand the true facts about the Falkland Islands," he said.

    Matt Ince, an analyst at the Royal United Services Institute (RUSI), a British defence think-tank, said Britain's strategic interests across Latin America could come under pressure unless Britain conveyed the message that "acceptance of Argentina's Falklands foreign policy is no longer a risk-free strategy."

    As the fourth largest investor in Latin America, accounting for 12 percent of foreign direct investment in Chile and 16 percent in Colombia, Britain was "not without options and economic clout," he said in an article on RUSI's website.

    "The UK has an opportunity to make it clear (to other South American countries) that there is a cost to supporting Argentina's posture - such as less favourable relations with the UK," he said.

    Mark Jones, political science professor at Rice University in the United States, said Argentina's strategy was partly to prevent the Falklands' oil from being so profitable that the islands could be financially independent of Britain.

    He said Britain's best response would be to let the Argentine diplomatic offensive die down. "Much of this is coming for domestic reasons in Argentina, this desire to distract from broader economic problems. If Britain doesn't yield at all, it is tough for the Argentine government to keep up. They have used most of the tools they have," he told Reuters.

    Fernandez was re-elected in a landslide last October but her popularity fell to a 13-month low of 42.1 percent in a poll in March. The economy, Latin America's third biggest, has boomed over the past nine years but is now cooling and Fernandez has cut back on some of her popular subsidies and social spending.

    British officials say the Falkland Islands, doing well from wool, fishing licences and now oil exploration, are self-sufficient economically, though London pays their defence costs of some 60 million pounds ($96 million) a year.

    When oil starts flowing, the islands will contribute to the cost of their defence, local assembly member Gavin Short told Reuters in February.

    The Argentine government has said it is committed to resolving the Falklands dispute peacefully.

    Still, some British legislators worry that the decision to scrap Britain's only aircraft carrier means Britain could not assemble a task force to retake the islands as it did in 1982.

    Defence experts say that is irrelevant because Britain has a strategy in place to defend the islands.

    Professor Michael Clarke, director-general of RUSI, says the construction of the Mount Pleasant air base on the Falklands, with two large runways, transforms the military equation.

    "As long as Britain occupies the base competently, Argentina could never mount a successful invasion," he said in an article on RUSI's web site.

    Britain has an infantry company, four Typhoon fighters, a Rapier air defence battery and other equipment on the islands and could fly in reinforcements within 18 hours, he said.

    While Britain had given its armed forces "world-class technologies, albeit in lower numbers," Argentina had added nothing since 1982, he wrote. "In military terms, the difference between their relative technologies is probably approaching 80-100 years," he said.

    (Editing by Tim Pearce)

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    Video: Marquis Jet Founder: Business Picking Up

    The NetJets corporate business is back again, according to Kenny Dichter, Marquis Jet founder/former CEO.

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    China online games market to grow 39 percent | Games Industry Blog

    China online games market to grow 39 percent

    China?s?online games market?is expected to exceed?US$9.2 billion by 2014 from US$6.6 billion last year, with?microclient version of games emerging?as a?trend and the number?of casual gamers growing across the region, research firms say.

    In a study released Wednesday, Pearl Research noted that the growth in online games which include?MMORPG (massively multiplayer online role-playing game), casual,?social and Web games, grew 32 percent last year.?It pointed to strong revenue showing by Chinese game operators, where the top 5 companies made a combined US$5.3 billion in revenues. The list was led by Tencent at US$2.5 billion, Netease at US$1 billion,?Shanda Games?at US$838 million, Changyou at US$485 million, and Perfect World at US$474 million.

    Pearl Research noted that microclient versions of games were growing in popularity. ?Microclient files are generally smaller, less than 50MB, compared to more than 1GB for a typical client-based game. This significantly cuts down a user?s download time of the game to under 15 minutes with a broadband connection.?The small size of microclient software is convenient and appealing to users, especially those users on game portals and social networking platforms,? it said.

    The research firm also pointed out that a key growth market for China would be Web games, which were accessible and user-friendly. This segment was expected to hit over US$1 billion in 2013, from US$800 million last year.

    Digital games to double in region
    In a separate research note released Thursday, Ovum forecasts revealed that the wider digital games market for Asia-Pacific would more than double over the next four years to reach US$30.3 billion in 2016. With a?compound annual growth rate (CAGR) of 18 percent,?the region?s expansion rate was a healthy 2 percent ahead of the global average and it contributed?over half of global retails sales in 2011.

    Neha Dharia, Ovum?s consumer telecoms analyst, said Asia-Pacific was already vital in terms of digital games retail sales and would?grow in importance in future.

    ?The region will drive the digital games market globally,??Dharia commented. ?The most significant retail sales contribution will come from the massive multiplayer online game (MMOG) sector, while the highest amount of growth in the Asia-Pacific market will come from mobile gaming.?

    Dharia added that with more and more casual players entering the market, gamer numbers will grow faster than retail sales, resulting in the erosion of average revenue per user (ARPU). Casual and social games will be vital to growing the number of gamers and bringing digital games into the mainstream.

    ?There is a considerable split between Asia-Pacific?s developed and emerging regions,? the analyst said. ?This results in a higher level of ARPU in?South Korea?and Japan than in China, for example, which has lower ARPU due to a large gamer base and the relatively low cost of games.?

    Ovum?s forecast for the Asia-Pacific market put the number of?online unique gamers at?over 1 billion in 2016, while there will be slightly fewer than 900 million mobile gamers in 2016.

    Dharia concluded: ?The growth of digital gaming in Asia-Pacific will give service providers an opportunity to grow their revenues in the region. Telcos, in particular, could harness this growth by offering gaming-specific connections, or bundling mobile games with data access packs. In addition, shifting the distribution of payments offline could encourage the number of in-app game purchases.?

    Source: ZD Net

    ?

    Wybe Schutte

    Wybe manages Gamesindustry.com, the Games Industry Black Book, the support staff and games sourcing projects. He joined the company several months after the start in 2007. He studied Business Administration at the VU University in Amsterdam.

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