Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/281807779?client_source=feed&format=rss
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বৃহস্পতিবার, ৩১ জানুয়ারী, ২০১৩
Zimmerman wants to delay trial for Martin shooting
ORLANDO, Fla. (AP) ? Attorneys for the former neighborhood watch volunteer charged with shooting Trayvon Martin to death on Wednesday asked for more time to prepare his case, saying prosecutors had been slow to turn over evidence.
At the same time, Zimmerman's lead attorney, Mark O'Mara, renewed his request for donations to George Zimmerman's legal defense, which he said could cost up to $1 million.
"The state has virtually unlimited resources to prosecute George," O'Mara said on Zimmerman's defense fund website. "To finance his defense, however, George relies on the generosity of individuals who believe he is innocent."
Spokesman Shawn Vincent said Zimmerman's attorneys want his second-degree murder trial to be moved from June to November. Zimmerman has pleaded not guilty.
A hearing in which Zimmerman will argue he was acting in self-defense is scheduled for April. The judge has said that hearing will be at least 45 days before the trial.
Prosecutors did not immediately respond to emails and phone calls about the defense request.
O'Mara said prosecutors had been slow to turn over evidence. As an example, he said someone from State Attorney's Office had removed Martin's cell phone from an evidence locker to have it sent to California for analysis, but the state has refused to give him any information about the agency and the type of tests being run on the phone. He also said prosecutors had made it difficult for O'Mara to get answers to administrative questions from a chief investigative agent and had refused to forward them other information on Martin and a witness.
O'Mara also asked the public to donate more money for his defense, saying on the web site that Zimmerman's defense fund has raised more than $314,000 since he was charged. Of that amount, $95,000 was spent on bail, almost $62,000 was spent on Zimmerman's living expenses during the past eight months and $56,100 was spent on security. The pricey living expenses were the result of Zimmerman having to stay at extended-stay hotels until he could find a place to rent after his bail conditions were changed to restrict him to Seminole County, Fla., according to the statement on the website said.
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বুধবার, ৩০ জানুয়ারী, ২০১৩
Animal shelters are real winners of 'Puppy Bowl'
This undated publicity photo provided by Animal Planet shows dogs playing on the field during "Puppy Bowl IX," in New York. The ?Puppy Bowl,? an annual two-hour TV special that mimics a football game with canine players, made its debut eight years ago on The Animal Planet. Dogs score touchdowns on a 10-by-19-foot gridiron carpet when they cross the goal line with a toy. (AP Photo/Animal Planet, Keith Barraclough)
This undated publicity photo provided by Animal Planet shows dogs playing on the field during "Puppy Bowl IX," in New York. The ?Puppy Bowl,? an annual two-hour TV special that mimics a football game with canine players, made its debut eight years ago on The Animal Planet. Dogs score touchdowns on a 10-by-19-foot gridiron carpet when they cross the goal line with a toy. (AP Photo/Animal Planet, Keith Barraclough)
This undated publicity photo provided by Animal Planet shows the Kitty half time show during "Puppy Bowl IX," in New York. The ?Puppy Bowl,? an annual two-hour TV special that mimics a football game with canine players, made its debut eight years ago on The Animal Planet. The show provides national exposure to the shelters across the country that provide the puppy athletes and the kittens that star in the halftime show, and introduces viewers to the different breeds and animals that need homes, animal workers say. (AP Photo/Animal Planet, Keith Barraclough)
This undated publicity photo provided by Animal Planet shows dogs playing on the field during "Puppy Bowl IX," in New York. The ?Puppy Bowl,? an annual two-hour TV special that mimics a football game with canine players, made its debut eight years ago on The Animal Planet. Dogs score touchdowns on a 10-by-19-foot gridiron carpet when they cross the goal line with a toy. (AP Photo/Animal Planet, Keith Barraclough)
This undated publicity photo provided by Animal Planet shows the Kitty half time show during "Puppy Bowl IX," in New York. The ?Puppy Bowl,? an annual two-hour TV special that mimics a football game with canine players, made its debut eight years ago on The Animal Planet. The show provides national exposure to the shelters across the country that provide the puppy athletes and the kittens that star in the halftime show, and introduces viewers to the different breeds and animals that need homes, animal workers say. (AP Photo/Animal Planet, Keith Barraclough)
This undated publicity photo provided by Animal Planet shows a dog, Fumble, during the kitty half-time show for "Puppy Bowl VIII," in New York. The ?Puppy Bowl,? an annual two-hour TV special that mimics a football game with canine players, made its debut eight years ago on The Animal Planet. Fumble, the spcaLA's entry in ?Puppy Bowl VIII," earned the game's Most Valuable Pup crown. (AP Photo/Animal Planet, Kimberly Holcombe)
LOS ANGELES (AP) ? There will be a winner and a loser every Super Bowl Sunday. But at the "Puppy Bowl," it's always a win for animal shelters.
The show provides national exposure to the shelters across the country that provide the puppy athletes and the kittens that star in the halftime show, and introduces viewers to the different breeds and animals that need homes, animal workers say. Many shelters see bumps in visits from viewers who are inspired to adopt a pet.
"It raises awareness for our shelter and others that take part," said Madeline Bernstein, president and CEO of the Society for the Prevention of Cruelty to Animals Los Angeles. "It shows dogs in a happy, playful, fun way, which makes people think, 'Gee, I could play with a dog too.' You hope it will also stimulate adoptions, and if not, at least a positive attitude toward dogs, rather than they are just hairy and smelly."
The "Puppy Bowl," an annual two-hour TV special that mimics a football game with canine players, made its debut eight years ago on The Animal Planet. Dogs score touchdowns on a 10-by-19-foot gridiron carpet when they cross the goal line with a toy. There is a Most Valuable Pup award, a water bowl cam, a new lipstick cam (it's in the lips of the toys), slow-motion cameras, hedgehog referees, a puppy hot tub and a blimp with a crew of hamsters. Bios on each puppy player flash across the screen during close-ups of the action, letting viewers know how to find each animal for adoption.
Most of the puppies, however, are usually adopted by airtime since the show is filmed months ahead, said executive producer Melinda Toporoff, who is working on her fifth "Puppy Bowl." But Bernstein said the point is to show that animals just like the ones on the show can be found at any shelter at any time.
"A lot of people have come in during the last year and said, 'I want a dog just like Fumble,'" she said, referring to spcaLA's player entry in "Puppy Bowl VIII" who earned the game's Most Valuable Pup crown.
About 300 puppies and kittens have been featured on "Puppy Bowl" over the last decade, according to Petfinder.com, the country's largest online pet adoption database that helps cast the show's animal stars.
"Shelters and rescues are at capacity, and pet adoption is the responsible way to add to your family," said Sara Kent, who oversees outreach to the 14,000 shelters and rescues that Petfinder works with.
The inaugural "Puppy Bowl," which was promoted as an alternative to the Super Bowl, had 22 puppies and was watched by nearly 6 million viewers. Nearly 9 million tuned in last year and another 1.4 million watched via video streams, Toporoff said. "Puppy Bowl IX" will feature 84 animals, including 21 kittens from a New York shelter for the halftime show, and 63 puppies from 23 shelters.
Only four of the puppies have yet to find new homes, Toporoff said. They include Tyson, Daphne and Sacha ? three pit bull mixes from the Pitter Patter Animal Rescue in Silver Lake, Wis., ? and Jenny, a terrier mix from the Pitty Love Rescue in Rochester, N.Y.
"I don't know if there's any bigger forum for getting something out on adoption. We make sure the message gets out there. We make clear that these dogs need homes and that all animals have come to us during the adoption process," Toporoff said.
Fumble, last year's MVP winner, was adopted before the show aired. Michael Wright, of New York, said he found out about Fumble's participation toward the end of the adoption process. He planned to watch this year's show to catch any flashbacks of last year's MVP playing his heart out.
"I'm not really a fan of football," he said, adding that he has renamed Fumble to Toby. "He fits the name Toby. He is so cute. I like the name Fumble, but I pictured someone dropping the ball. He wasn't a Fumble," Wright said.
Each year, recruiting for the show is a logistical challenge for Kent and her crew of 80-plus. This year's show was particularly worrisome because taping was scheduled for October 2012 ? just after Superstorm Sandy hit the East Coast.
"We worried about the puppies, kittens and hedgehogs that may have been directly impacted or unable to travel due to Sandy," Kent said.
The New York studio where the game was supposed to be taped lost power, but the taping couldn't be postponed for too long given how quickly puppies grow. Another studio further uptown that had both power and space was found, and "amazingly, the crew was able to reschedule the shoot for only a week later and all the animals were still able to attend," Kent said.
Bernstein said they try to find rambunctious, energetic puppies to enter in the bowl though even if a dog falls asleep on its way to the end zone, it can be funny. Puppies chosen for the show have to be between 10 and 15 weeks old, healthy and sturdy enough to be on the field with playmates. All breeds are considered because "we try to reflect what's out there in the adoption world. A lot of those breeds are mixed," Toporoff said.
Producers also were trying to find ways to incorporate older animals into the show, since shelters have more trouble finding homes for them than they do puppies and kittens, Toporoff said.
As with all reality TV shows, the behind-the-scenes casting can lead to problems. Viewers often come in seeking a dog just like one on the show, and "then the lawyer brain kicks in, and you have to make sure you let everybody know not every dog plays football," said Bernstein, who is also an attorney. "People will adopt the kind of dog they see in the movie and they'll expect their Dalmatian to know how to use a word processor and not understand that was a cartoon."
"Some dogs like to play more than others. But don't come in thinking every Chihuahua can play football," she said.
The "Puppy Bowl" airs on Feb. 3 from 3 p.m. to 5 p.m. in all time zones and will keep repeating until 3 a.m. The Super Bowl starts at 6:30 p.m. ET and 3:30 p.m. PT.
___
Online:
http://animal.discovery.com/tv-shows/puppy-bowl
http://www.spcaLA.com
http://www.petfinder.com/petdetail/24414038 (Tyson)
http://www.petfinder.com/petdetail/24413997 (Daphne)
http://www.petfinder.com/petdetail/24413979 (Sacha)
http://www.petfinder.com/petdetail/24393351 (Jenny)
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Facebook?s Q4 Revenue Rises 40% To $1.59B, Shares Down Slightly In After-Hours
Facebook said its fourth quarter revenue rose 40 percent year-over-year to $1.59 billion. Mobile revenues grew to make up 23 percent of the company’s total and mobile monthly active users rose to 680 million, or up 57 percent year-over-year. The company beat analysts estimates, but shares initially tumbled by as much as 8 percent in after-hours trading. They’re now down only 0.3 percent to $31.15. Analysts had forecast that revenue rose 34 percent to $1.52 billion last quarter, according to the median estimate from a Bloomberg survey of analysts. Facebook also beat analysts’ estimates on EPS and net income with about $65 million in net income to an average estimate of $45.8 million, and EPS excluding certain changes of 17 cents, compared to the forecast of 15 cents a share from the same Bloomberg survey. In the same time a year ago, Facebook earned $302 million in net income on $1.131 billion in revenue. As for the revenue breakdown, Facebook has two primary revenue sources: advertising and payments. Ad revenue was $1.33 billion, up 41 percent from the year before. Payments revenue came in at $256 million, but was essentially flat year-over-year if you factor in some accounting changes that required Facebook to count four months of revenue instead of the normal three for the quarter. Facebook’s shares have risen 17 percent since the beginning of the year, on bets that the company’s aggressive push into mobile advertising is paying off. Mobile platforms now account for 23 percent of the company’s revenue, up from 14 percent in the third quarter. Facebook has since been much more forceful with putting sponsored stories into the mobile news feed and pushing app install ads. Ad platform Kenshoo told us earlier this month that it’s now seeing 20 percent of all Facebook ad spend going to mobile. Facebook still has to convince investors that it’s moving fast enough to accommodate a dramatic shift in consumer behavior to mobile devices away from the web. For the first time, Facebook had more mobile daily active users than ones on the web last quarter. Yet mobile revenue is still less than one-third of the size of the company’s web revenues. At the same time, the company has launched a host of new initiatives in the second half of 2012 that may finally start to show traction. In August, Facebook launched a form of search-based advertising called SponsoredSource: http://feedproxy.google.com/~r/Techcrunch/~3/M7NpMYwIet8/
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Engadget HD Podcast 334 - 01.28.2013
Did you miss us? Richard and Ben needed a second dose of recovery time after all the madness from our post-CES podcast, but now we're back to normalcy. This week, we do our best to keep the earnings numbers to a minimum and, instead, focus on topics like the amazing CGI effects from Jurassic Park and Ben's fascination with the moon landing conspiracy debunks. Oh, yeah, and the notable HD news from the past week. All that and maybe more, so get to listening down below.
Hosts: Ben Drawbaugh (@bjdraw), Richard Lawler (@rjcc)
Producer: Joe Pollicino (@akaTRENT)
Hear the podcast
Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/Ob42W9AxFOc/
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মঙ্গলবার, ২৯ জানুয়ারী, ২০১৩
How brain cells shape temperature preferences
Jan. 29, 2013 ? While the wooly musk ox may like it cold, fruit flies definitely do not. They like it hot, or at least warm. In fact, their preferred optimum temperature is very similar to that of humans -- 76 degrees F.
Scientists have known that a type of brain cell circuit helps regulate a variety of innate and learned behavior in animals, including their temperature preferences. What has been a mystery is whether or not this behavior stems from a specific set of neurons (brain cells) or overlapping sets.
Now, a new study from The Scripps Research Institute (TSRI) shows that a complex set of overlapping neuronal circuits work in concert to drive temperature preferences in the fruit fly Drosophila by affecting a single target, a heavy bundle of neurons within the fly brain known as the mushroom body. These nerve bundles, which get their name from their bulbous shape, play critical roles in learning and memory.
The study, published in the January 30, 2013 edition of the Journal of Neuroscience, shows that dopaminergic circuits -- brain cells that synthesize dopamine, a common neurotransmitter -- within the mushroom body do not encode a single signal, but rather perform a more complex computation of environmental conditions.
"We found that dopamine neurons process multiple inputs to generate multiple outputs -- the same set of nerves process sensory information and reward-avoidance learning," said TSRI Assistant Professor Seth Tomchik. "This discovery helps lay the groundwork to better understand how information is processed in the brain. A similar set of neurons is involved in behavior preferences in humans -- from basic rewards to more complex learning and memory."
Using imaging techniques that allow scientists to visualize neuron activity in real time, the study illuminated the response of dopaminergic neurons to changes in temperature. The behavioral roles were then examined by silencing various subsets of these neurons. Flies were tested using a temperature gradient plate; the flies moved from one place to another to express their temperature preferences.
As it turns out, genetic silencing of dopaminergic neurons innervating the mushroom body substantially reduces cold avoidance behavior. "If you give the fly a choice, it will pick San Diego weather every time," Tomchik said, "but if you shut down those nerves, they suddenly don't mind being in Minnesota."
The study also showed dopaminergic neurons respond to cooling with sudden a burst of activity at the onset of a drop in temperature, before settling down to a lower steady-state level. This initial burst of dopamine could function to increase neuronal plasticity -- the ability to adapt -- during periods of environmental change when the organism needs to acquire new associative memories or update previous associations with temperature changes.
The study, "Dopaminergic Neurons Encode a Distributed, Asymmetric Representation of Temperature in Drosophila," was supported by the National Institute of Mental Health of the National Institutes of Health (grant number K99 MH092294).
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Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/rKKVO8cdyJ8/130129190251.htm
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iMore show 334: Elegant aluminium iOS
Rene re-visits skeuomorphism one last time, then talks 500px, Vine, and Apple's problem with porn, Q1 2013 financial results, and iPhone 5S, iPad 5, and iPad mini 2, cheap iPhone and big iPhone rumors. This is the iMore show.
- Subscribe via iTunes: Audio | Video
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Show notes
- Imagining a skeuomorphic-free, all-aluminium iOS 7
- Editor's desk: Macworld|iWorld 2013 bound!
- Shocker: People are uploading porn to Vine
- Apple removes photography app 500px over nudity concerns
- Verizon sells 9.8 million smartphones in Q4 2012, 6.2 million of which are iPhones
- Apple announces Q1 2013 results, 47.8 million iPhone, 22.9 million iPads, 12.7 million iPods, 4.1 million Macs and $54 billion in revenue
- AT&T announces Q4 2012 results, sold 10.2 million smartphones, 8.6 million of which were iPhones
- Tim Cook reportedly uses Town Hall meeting to address Android, Wall Street, and more
- Regarding iPad 5, iPad mini 2, iPhone 5S, and other rumored Apple hardware
- Would you want an iPad 5 that looks and feels just like an iPad mini?
- Imagining a 5-inch iPhone
- 128GB iPhones get rumored again, this time thanks to iOS 6.1
Hosts
- Rene Ritchie (@reneritchie)
Credits
You can reach all of us on Twitter @iMore, or you can email us at podcast@imore.com or just leave us a comment below.
For all our podcasts -- audio and video -- including the iMore show, ZEN and TECH, Iterate, Debug, Ad hoc, and more, see MobileNations.com/shows
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Source: http://feedproxy.google.com/~r/TheIphoneBlog/~3/DiPNwaDoBC8/story01.htm
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THE RESET: Guns, immigration topping week's agenda
FILE - In this Oct. 5, 2011 file photo, Sen. Marco Rubio, R-Fla., speaks at the Newseum in Washington. In an opinion piece published Sunday Jan. 27, 2013 in the Las Vegas Review-Journal, Rubio wrote that the existing system amounts to "de facto amnesty," and he called for "commonsense reform." (AP Photo/Haraz N. Ghanbari, File)
FILE - In this Oct. 5, 2011 file photo, Sen. Marco Rubio, R-Fla., speaks at the Newseum in Washington. In an opinion piece published Sunday Jan. 27, 2013 in the Las Vegas Review-Journal, Rubio wrote that the existing system amounts to "de facto amnesty," and he called for "commonsense reform." (AP Photo/Haraz N. Ghanbari, File)
John Crossen, of Montoursville, with Big John's Guns, closes a case of handguns during the Allentown Gun Show Sunday morning at the Rodeway Inn Conference Center in South Whitehall Township, Pa. Jan. 27, 2013. (AP Photo/The Express-Times, Matt Smith)
FILE - In this Jan. 25, 2013 file image taken from video and provided by CBS, President Barack Obama, center, and Secretary of State Hillary Rodham Clinton speak with ?60 Minutes? correspondent Steve Kroft, left, in the Blue Room of the White House in Washington. The interview will air Sunday, Jan. 27 during the ?60 Minutes? telecast on CBS. (AP Photo/CBS, File)
A week into his second term, President Barack Obama is temporarily turning from perpetual political fights over the national debt, government borrowing, spending and taxing to tackle two other big issues: immigration and gun-law overhaul.
With Congress delaying a debt limit showdown until May 18, the White House postponing its annual budget submission until March and House Speaker John Boehner struggling to maintain Republican unity, this could be the time to strike.
National public opinion polls show a majority of Americans now support easing immigration laws and tightening federal gun restrictions.
That's not to say either fight will be easy. Both immigration and guns remain hot-button issues in Congress
The president met Monday with police chiefs from three towns that experienced mass shootings in 2012: Aurora, Colo.; Oak Creek, Wis., and Newton, Conn. "We recognize that this is an issue that elicits a lot of passion all across the country," Obama said.
He hopes public outrage over recent shootings strengthens his hand on curbing gun violence.
Meanwhile, a bipartisan Senate group Monday presented a new framework for overhauling the nation's immigration laws, including a path to citizenship for the 11 million illegal immigrants already here. Obama presses his case for immigration-law changes Tuesday in Las Vegas.
The White House also believes the political math of last November's election ? in which Obama won overwhelming Hispanic support ? helped soften GOP opposition to liberalizing immigration laws.
"What's changed, honestly, is that there is a new ... appreciation on both sides of the aisle ? including maybe more importantly on the Republican side of the aisle ? that we have to enact a comprehensive immigration reform bill," Sen. John McCain, R-Ariz., said Sunday on ABC.
Even so, the new Senate immigration proposal could face strong opposition in the Republican-controlled House.
And despite growing public support for gun curbs, the pro-gun lobby remains a potent force.
___
Follow Tom Raum on Twitter: http://www.twitter.com/tomraum
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সোমবার, ২৮ জানুয়ারী, ২০১৩
DNA-repairing protein may be key to preventing recurrence of some cancers
![[ Back to EurekAlert! ]](http://www.eurekalert.org/images/back2e.gif){kind=small}
Public release date: 28-Jan-2013[ | E-mail |
Share ] Contact: Zenaida Kotala
zenaida.kotala@ucf.edu
407-823-6120
University of Central Florida
Just as the body can become resistant to antibiotics, certain methods of killing cancer tumors can end up creating resistant tumor cells. But a University of Central Florida professor has found a protein present in several types of cancer, including breast and ovarian cancer, which could be helpful in preventing tumors from coming back.
The protein, KLF8, appears to protect tumor cells from drugs aimed at killing them and even aid the tumor cells' ability to regenerate.
"All cells have a DNA-repair mechanism," explained Jihe Zhao, a medical doctor and researcher who in the past few months has published several articles related to the protein in the Journal of Biological Chemistry (http://www.jbc.org/content/287/52/43720) and Oncogene (http://www.nature.com/onc/journal/vaop/ncurrent/full/onc2012545a.html), among others. "That's why we survive constant DNA damage threats. But KLF8 is overexpressed in specific cancers, such as breast cancer and ovarian cancer. The thought is that if we can stop it from switching on, we may be able to stop the tumors from coming back as part of therapy. We still need to do a lot more research, but it is plausible."
There are between 2.5 million and 2.7 million women who have breast cancer in the United States and 10 to 20 percent will experience a recurrence, according to the American Cancer Society. Current treatment options, depending on the stage of cancer, include surgical removal followed by chemotherapy using a combination of cancer killing drugs. Each year about 22,200 women are also diagnosed with ovarian cancer.
DNA damage-based chemotherapies depend on failure of cancer cells to repair the DNA damage and subsequent cell death, according to the journal article. Aberrant high levels of DNA repair function in the cells likely increase not only the resistance of the cells to such therapies but also the malignancy of the cells due to improper DNA repair-mediated genomic and chromosomal instability.
In the study, Zhao's team tested one specific cancer-fighting drug used in the treatment of breast cancer to determine the role of the protein.
"Indeed, our results have clearly linked the KLF8-promoted DNA repair to the cell resistance to doxorubicin-induced cell death," Zhao said. "It remains to be determined whether KLF8 plays a similar role in repairing DNA damage caused by other types of genotoxic agents such as DNA alkylating agents and ionizing radiation."
Even so, the results suggest that in addition to enhancing the drug resistance of the cancer cells, KLF8 could play a role in disturbing genomic integrity through its aberrant DNA repair function and subsequently contribute to aggressive progression of cancer.
###
Zhao, an associate professor, moved his team to UCF's Burnett School of Biomedical Sciences at the College of Medicine in 2010. Previously he was at Albany Medical College as an assistant professor and before that he spent six years in post-doctoral training in Cornell University, Ithaca, N.Y. He earned his M.D. from Chinese Medical University, Shenyang, China, and Ph.D. in cancer cell biology from Tohoku University Faculty of Medicine, Sendai, Japan. He sits on the editorial boards of several peer-reviewed journals related to cancer research and reviews research articles for many prestigious journals including Cancer Research, Oncogene, Molecular Cell, Nanomedicine, and Journal of Biological Chemistry, to name a few. His research programs are funded by National Cancer Institute of National Institute of Health, American Cancer Society, Susan Komen for the Cure Breast Cancer Foundation, and others.
50 Years of Achievement: The University of Central Florida, the nation's second-largest university with nearly 60,000 students, is celebrating its 50th anniversary in 2013. UCF has grown in size, quality, diversity and reputation, and today the university offers more than 200 degree programs at its main campus in Orlando and more than a dozen other locations. Known as America's leading partnership university, UCF is an economic engine attracting and supporting industries vital to the region's success now and into the future. For more information, visit http://today.ucf.edu.
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Public release date: 28-Jan-2013[ | E-mail |
Share ] Contact: Zenaida Kotala
zenaida.kotala@ucf.edu
407-823-6120
University of Central Florida
Just as the body can become resistant to antibiotics, certain methods of killing cancer tumors can end up creating resistant tumor cells. But a University of Central Florida professor has found a protein present in several types of cancer, including breast and ovarian cancer, which could be helpful in preventing tumors from coming back.
The protein, KLF8, appears to protect tumor cells from drugs aimed at killing them and even aid the tumor cells' ability to regenerate.
"All cells have a DNA-repair mechanism," explained Jihe Zhao, a medical doctor and researcher who in the past few months has published several articles related to the protein in the Journal of Biological Chemistry (http://www.jbc.org/content/287/52/43720) and Oncogene (http://www.nature.com/onc/journal/vaop/ncurrent/full/onc2012545a.html), among others. "That's why we survive constant DNA damage threats. But KLF8 is overexpressed in specific cancers, such as breast cancer and ovarian cancer. The thought is that if we can stop it from switching on, we may be able to stop the tumors from coming back as part of therapy. We still need to do a lot more research, but it is plausible."
There are between 2.5 million and 2.7 million women who have breast cancer in the United States and 10 to 20 percent will experience a recurrence, according to the American Cancer Society. Current treatment options, depending on the stage of cancer, include surgical removal followed by chemotherapy using a combination of cancer killing drugs. Each year about 22,200 women are also diagnosed with ovarian cancer.
DNA damage-based chemotherapies depend on failure of cancer cells to repair the DNA damage and subsequent cell death, according to the journal article. Aberrant high levels of DNA repair function in the cells likely increase not only the resistance of the cells to such therapies but also the malignancy of the cells due to improper DNA repair-mediated genomic and chromosomal instability.
In the study, Zhao's team tested one specific cancer-fighting drug used in the treatment of breast cancer to determine the role of the protein.
"Indeed, our results have clearly linked the KLF8-promoted DNA repair to the cell resistance to doxorubicin-induced cell death," Zhao said. "It remains to be determined whether KLF8 plays a similar role in repairing DNA damage caused by other types of genotoxic agents such as DNA alkylating agents and ionizing radiation."
Even so, the results suggest that in addition to enhancing the drug resistance of the cancer cells, KLF8 could play a role in disturbing genomic integrity through its aberrant DNA repair function and subsequently contribute to aggressive progression of cancer.
###
Zhao, an associate professor, moved his team to UCF's Burnett School of Biomedical Sciences at the College of Medicine in 2010. Previously he was at Albany Medical College as an assistant professor and before that he spent six years in post-doctoral training in Cornell University, Ithaca, N.Y. He earned his M.D. from Chinese Medical University, Shenyang, China, and Ph.D. in cancer cell biology from Tohoku University Faculty of Medicine, Sendai, Japan. He sits on the editorial boards of several peer-reviewed journals related to cancer research and reviews research articles for many prestigious journals including Cancer Research, Oncogene, Molecular Cell, Nanomedicine, and Journal of Biological Chemistry, to name a few. His research programs are funded by National Cancer Institute of National Institute of Health, American Cancer Society, Susan Komen for the Cure Breast Cancer Foundation, and others.
50 Years of Achievement: The University of Central Florida, the nation's second-largest university with nearly 60,000 students, is celebrating its 50th anniversary in 2013. UCF has grown in size, quality, diversity and reputation, and today the university offers more than 200 degree programs at its main campus in Orlando and more than a dozen other locations. Known as America's leading partnership university, UCF is an economic engine attracting and supporting industries vital to the region's success now and into the future. For more information, visit http://today.ucf.edu.
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Source: http://www.eurekalert.org/pub_releases/2013-01/uocf-dpm012513.php
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Video: Tomorrow In :30
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Stepparenting & Blended Families 2017: Smart Stepdad, The: Steps ...
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Smart Stepdad, The: Steps to Help You Succeed
by Ron L. Deal 
(7)
New!: $13.99 $11.19 (as of 01/26/2013 07:09 PST)
67 Used! | New! from $6.91 (as of 01/26/2013 07:09 PST)
Stepparenting & Blended Families
While resources abound for stepmothers, stepfathers are often left to travel a difficult road without clear directions. Ron Deal offers advice for men navigating the stepfamily minefield, including how to connect with stepchildren, being a godly role model, how to discipline, dealing with the biological dad, and keeping the bond strong with one's new spouse. He gives perspective on what the kids are going through and why things don't work the same as in a biological family. The Smart Stepdad provides essential guidelines to help stepfathers not only survive but succeed as both dad and husband.
- Rank: #80949 in Books
- Published on: 2011-04-01
- Original language: English
- Number of items: 1
- Dimensions: 8.27" h x .63" w x 5.31" l, .65 pounds
- Binding: Paperback
- 256 pages
Source: http://popstepparentingblendedfamili137.blogspot.com/2013/01/smart-stepdad-steps-to-help-you-succeed.html
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রবিবার, ২৭ জানুয়ারী, ২০১৩
Religious Groups Fight Obamacare Birth Control Mandate
New York Times:
In a flood of lawsuits, Roman Catholics, evangelicals and Mennonites are challenging a provision in the new health care law that requires employers to cover birth control in employee health plans ? a high-stakes clash between religious freedom and health care access that appears headed to the Supreme Court.
Read the whole story at New York Times
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HBT: 'Fake to third, throw to first' move now a balk
In town for SoxFest on Saturday, Frank Thomas was his typical direct self in expressing his desire to enter Cooperstown next winter and in labeling the numbers of steroid users ?fake.? CSNChicago.com?s Dan Hayes has the story, which includes a video interview. Thomas has a very clear sense of his place in history, and he?
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Video: The Comic Book Murder, Vol. 2, Part 6
Dateline NBC
'Dateline NBC,' the signature broadcast for NBC News in primetime, premiered in 1992. Since then, it has been pioneering a new approach to primetime news programming. The multi-night franchise, supplemented by frequent specials, allows NBC to consistently and comprehensively present the highest-quality reporting, investigative features, breaking news coverage and newsmaker profiles.
Source: http://www.msnbc.msn.com/id/3032600/vp/50594653#50594653
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শনিবার, ২৬ জানুয়ারী, ২০১৩
NYC mayor says Latino group has 'sold its soul' over drinks issue
NEW YORK ?? Mayor Michael Bloomberg says the Hispanic Federation has ?sold its soul? by joining a court fight against New York City?s size limit on sugary drinks.
On his weekly WOR Radio show Friday, Bloomberg also criticized the NAACP?s New York state branch. That group also is involved in the effort to block the rule from taking effect on March 12.
The groups say the measure will hurt minority-owned businesses while doing little to curb obesity.
?The Hispanic Federation has been a leader in advocating for increased healthy living and fitness opportunities for more than a decade and has organized annual health and fitness community events to directly combat obesity and other health issues impacting New York?s Latino community,? said Jos? Calderon, President of the Hispanic Federation, in a statement.??We believe in a comprehensive attack on New York?s obesity crisis that stresses public school physical and health education and community wellness programs. Banning large sugary drinks in a selective fashion with tons of loopholes will do little to address obesity in the Latino community and will unfairly hurt small, minority-owned delis and bodegas. We should work together to solve this crisis by increasing funds for school and community health and fitness programs and by educating and empowering New Yorkers to make healthier lifestyle choices.?
Bloomberg said children who are the most obese tend to live in the city?s minority neighborhoods.
He asked how NAACP officials ?can look at themselves in the mirror knowing they are deliberately hurting? the children?s life expectancy.
RELATED: Hispanic Federation and NAACP come out against NYC?s large sugary drinks ban
Kristina Puga contributed to this report.
Source: http://nbclatino.com/2013/01/25/nyc-mayor-says-latino-group-has-sold-its-soul-over-drinks-issue/
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শুক্রবার, ২৫ জানুয়ারী, ২০১৩
SmackDown Five-Point Preview: Jan. 25, 2013
All WWE programming, talent names, images, likenesses, slogans, wrestling moves, trademarks, logos and copyrights are the exclusive property of WWE, Inc. and its subsidiaries. All other trademarks, logos and copyrights are the property of their respective owners. ? 2012 WWE, Inc. All Rights Reserved. This website is based in the United States. By submitting personal information to this website you consent to your information being maintained in the U.S., subject to applicable U.S. laws. U.S. law may be different than the law of your home country. WrestleMania XXIX (NY/NJ) logo TM & ? 2012 WWE. All Rights Reserved. The Empire State Building design is a registered trademark and used with permission by ESBC.
Source: http://www.wwe.com/shows/smackdown/2013-01-25/five-point-preview
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Movie Reviews: Parker, Hansel and Gretel: Witch Hunters ...
Editor's Note: All reviews and information aggregated from?Moviefone and RottenTomatoes.
Want to catch a movie this weekend? Here is Patch's roundup of movies playing at Lakeville 21 TheatreMarcus Rosemount Cinema, Apple Valley?s Carmike Cinema and Great Clips IMAX Theatre at the Minnesota Zoo.
New this weekend:
Parker
One sentence plot: Parker (Jason Statham) is a professional thief who lives by a personal code of ethics: Don't steal from people who can't afford it and don't hurt people who don't deserve it.
Moviefone viewer score: 85
Reviews:
"How does Hackford fall so far off the rails with the pedestrian crime thriller Parker, based on the 19th book in the Parker series by the late Donald E. Westlake (no slouch himself, with scripting credits on The Grifters and The Stepfather)? For starters, Westlake didn?t pen this script, and the John J. McLaughlin screenplay is a mess, both highly ludicrous and predictable. McLaughlin ? yeah, the same dude who wrote Black Swan and the recent Hitchcock ? really treads in the shallow end of the gene pool here." Montreal Gazzette. Full review
"'Parker' plays like the bloodiest promotional video ever made for Palm Beach tourism. Stabbings, explosions and furniture-smashing brawls occur at some of the ritziest (and name-checked) locations within the sun-splashed, pastel-soaked slab of Florida opulence. Kinda gives a whole new meaning to the idea of The Breakers." Star Tribune. Full review
?
Hansel and Gretel: Witch Hunters
One sentence plot: After getting a taste for blood as children, Hansel (Renner) and Gretel (Arterton) have become the ultimate vigilantes, hell bent on retribution.
Moviefone viewer score: 91
Reviews:
"High-concept pitch or no, the movie doesn?t really work. They were shooting for sort of a witch-hunting 'Zombieland,' an F-bomb-riddled 'Van Helsing' packed with comical anachronisms ? a Bavarian forest past with witch trials, pump shotguns and primitive Tasers, where bottles of milk have woodcut pictures of 'missing children' on the labels." Norfolk Daily News. Full review
"In the 3D?Witch Hunters, the kids were taken into the woods and left on their own by their father. They stumble into a candy-covered witch house, are taken prisoner and when they figure a way out of their fix - working as a team - they've found their calling. They'll track, shoot, stab, behead and burn witches. Whatever it takes." The Age. Full review
"Even though their skillsets are essentially limited to finding and killing witches, Hansel and Gretel decide to rescue the children themselves. Really, the film should have been called Hansel and Gretel: Occasional Child Recoverers, but that doesn't scan so well. So, who could have abducted the children? A witch?" The Guardian. Full review
Other movies in theaters:
Mama
One sentence plot: Guillermo del Toro presents 'Mama', a supernatural thriller that tells the haunting tale of two little girls who disappeared into the woods the day that their parents were killed.
Moviefone viewer score: 84
Reviews:
"What's under the bed? Who's behind that door? What's making those vaguely satanic noises? These and other thought-provoking questions are entertained in Mama, a visually polished but overly repetitive chiller." Variety. Full Review
"It never hits the high notes of Mr. del Toro's own films or successfully weaves between reality and fantasy as it should." New York Observer. Full Review
"Nothing in the movie is quite original, yet Muschietti, expanding his original short, knows how to stage a rip-off with frightening verve." Entertainment Weekly. Full Review
Do you plan on seeing this movie? Please tell us what you thought in the comments below.
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Broken City
One sentence plot: The mayor of New York City hires a disgraced ex-cop to identify his wife's lover, setting into motion a scandalous series of events in this post-noir thriller from director Albert Hughes.
Moviefone viewer score: 91
Reviews:
"'Broken City' is an evocative and over-ambitious title for a so-so political potboiler that wants to be a gritty, expansive epic of moral and urban decay." Variety. Full review.
"Broken City tells a sordid tale of big city corruption that would have made for a fine film noir sixty years ago but feels rather contrived and unbelievable in the setting of contemporary New York... It's never really convincing that the characters would do some of the far-fetched things required of them by the script, resulting in a sense of detachment that is never helpful for a thriller." The Hollywood Reporter. Full review.
Do you plan on seeing this movie? Please tell us what you thought in the comments below.
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Gangster Squad
One sentence plot: Ruthless, Brooklyn-born mob king Mickey Cohen (Sean Penn) runs the show in this town, reaping the ill-gotten gains from the drugs, the guns, the prostitutes and--if he has his way--every wire bet placed west of Chicago.
Moviefone viewer score: 90
Moviefone critic score: 43
Reviews:
?The cops play things as dirty as the crooks in Gangster Squad, an impressively pulpy underworld-plunger that embellishes on a 1949 showdown between a dedicated team of LAPD officers and Mob-connected Mickey Cohen (Sean Penn) for control of the city.? Variety. Full Review.
?Made up of synthetics rather than whole cloth, this lurid concoction superficially gets by thanks to a strong cast and jazzy period detail, but its cartoonish contrivances fail to convince and lack any of the depth, feeling or atmosphere of genre stand-bearers like ?L.A. Confidential.?? The Hollywood Reporter. Full Review.
?Despite the unrelenting action and the terrific cast, Gangster Squad comes up more scattered than successful.? Austin Chronicle. Full Review.
Do you plan on seeing this movie? Please tell us what you thought in the comments below.
- - - - -
Zero Dark Thirty
One sentence plot: The filmmaking duo behind The Hurt Locker (Kathryn Bigelow and Mark Boal) takes on the hunt for -- and the killing of -- Osama bin Laden in this Annapurna Pictures production that tracks SEAL Team Six, the special-ops team who eventually brought down the terrorist leader.
Moviefone viewer score: 63
Moviefone critic score: 95
Reviews:
?Telling a nearly three-hour story with an ending everyone knows, Bigelow and Boal have managed to craft one of the most intense and intellectually challenging films of the year.? The Guardian. Full Review.
?Like the fictional Clarice Starling in ?The Silence of the Lambs,? Maya is a consummate professional who brilliantly performs her job in an often hostile work environment.? New York Post. Full Review.
?A monumental achievement that documents a coordinated and complicated response to a monumental tragedy.? Philadelphia Enquirer. Full Review.
Do you plan on seeing this movie? Please tell us what you thought in the comments below.
----
The Hobbit: An Unexpected Journey
One sentence plot: The adventure follows the journey of title character Bilbo Baggins, who is swept into an epic quest to reclaim the lost Dwarf Kingdom of Erebor from the fearsome dragon Smaug.
Moviefone viewer score: 72 percent
Moviefone critic score: 58
Reviews:
?Charming, spectacular, technically audacious; in short, everything you expect from a Peter Jackson movie. A feeling of familiarity does take hold in places, but this is an epically entertaining first course.? Total Film. Full Review.
?A mesmerizing study in excess, Peter Jackson and company's long-awaited prequel to the Lord of the Rings saga is bursting with surplus characters, wall-to-wall special effects, unapologetically drawn-out story tangents and double the frame rate (48 over 24) of the average movie.? Time Out New York. Full Review.
?I'm holding the filmmaker responsible for getting us all back again - to feelings of excitement and delight. Vital as they are, Gollum and Bilbo can only do so much to keep us enchanted. Is Jackson able to sustain the magic in two more installments? I peer into Tolkien's Misty Mountains and embrace the journey.? Entertainment Weekly. Full Review.
Do you plan on seeing this movie? Have you seen it already? Leave a review of the film with a comment below.
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Django Unchained
One sentence plot: Set in the South two years before the Civil War, Django Unchained stars Academy Award winner Jamie Foxx as Django, a slave who forms an unlikely partnership with German-born bounty hunter Dr. King Schultz.
Moviefone viewer score: 73
Moviefone critic score: 80
Reviews:
"A sharp shock of a film in an Awards season very full of movies so noble they become immobile. It's wildly unlikely to get much love from the Academy, and that's fine-bluntly, it's too good for them. With its bloody stew of history and hysteria, action taken from movies and atrocities taken from fact, Django isn't just a movie only America could make-it's also a movie only America needs to." Boxoffice Magazine.?Full Review.
"Exactly what you might expect from the fearless, controversial director of "Pulp Fiction" - it's overlong, raunchy, shocking, grim, exaggerated, self-indulgently over-the-top and so politically incorrect it demands a new definition of the term. It is also bold, original, mesmerizing, stylish and one hell of a piece of entertainment." Rex Reed of New York Observer.?Full Review.
"Django Unchained also has the pure, almost meaningless excitement which I found sorely lacking in Tarantino's previous film, Inglourious Basterds, with its misfiring spaghetti-Nazi trope and boring plot. I can only say Django delivers, wholesale, that particular narcotic and delirious pleasure that Tarantino still knows how to confect in the cinema, something to do with the manipulation of surfaces. It's as unwholesome, deplorable and delicious as a forbidden cigarette." Peter Bradshaw of The Guardian.?Full Review.
Do you plan on seeing this movie? Have you seen it already? Leave a review of the film with a comment below.
?----
Les Miserables
One sentence plot: Set against the backdrop of 19th-century France, Les Miserables tells an enthralling story of broken dreams and unrequited love, passion, sacrifice and redemption, in a timeless testament to the survival of the human spirit.
Moviefone viewer score: 81
Moviefone critic score: 63
Reviews:
"Stirring and striking, Hooper's epic musical won't be wanting for awards and plaudits. Danny Cohen's cinematography is stunning and Hathaway's Oscar is guaranteed." Neil Smith of Total Film.?Full Review.
"Russell Crowe's pained vocal stylings (they sound more like barks) as relentless Inspector Javert can be forgiven after hearing Hugh Jackman's old-pro fluidity in the central role of Jean Valjean, hiding a criminal past." Joshua Rothkopf of Time Out New York.?Full Review.
"Fortunately, this sprawling epic is well-anchored. There cannot be a better big-screen showman than Jackman." Elizabeth Weitzman of New York Daily News.?Full Review.
Do you plan on seeing this movie? Have you seen it already? Leave a review of the film with a comment below.
?----
This is 40
One sentence plot: Five years after writer/director Judd Apatow introduced us to Pete and Debbie in 'Knocked Up', Paul Rudd and Leslie Mann reprise their roles as a husband and wife both approaching a milestone meltdown in 'This Is 40', an unfiltered, comedic look inside the life of an American family.
Moviefone viewer score: 53
Moviefone critic score: 58
Reviews:
"This Is 40 isn't always hilarious, but it's ticklishly honest and droll about all the things being a parent can do to a relationship. And why it's still worth it." Owen Gleiberman of Entertainment Weekly.?Full Review.
"Judd Apatow's instincts have rarely been sharper, wiser or more relatable than in This Is 40, an acutely perceptive, emotionally generous laffer about the joys and frustrations of marriage and middle age." Justin Chang of Variety.?Full Review.??
"In short, This Is 40, in tried and true Apatowian style, mixes weighty issues about intimacy and cohabitation with astute and smart-alecky pop culture references, crude bathroom jokes, stoner riffs, boob ogling, and existential angst." Steven Rea of Philadelphia Inquirer.?Full Review.
Do you plan on seeing this movie? Have you seen it already? Leave a review of the film with a comment below.
- - - - -
Jack Reacher
One sentence plot: The Usual Suspects' Christopher McQuarrie brings Lee Child's Jack Reacher character to the big screen with this Paramount Pictures release starring Tom Cruise as the lone-wolf investigator on the hunt for a murderous sniper.
Moviefone viewer score: 65
Moviefone critic score: 49
Reviews:
"In terms of pure pop entertainment value, you'll be hard-pressed to find a more smartly constructed, beautifully shot, pulse-pounding movie this holiday season." Drew Taylor of The Playlist.?Full Review.
"A superior thriller, with Cruise and McQuarrie slotting together like a bullet in a clip. Like Reacher on the firing range, the aim isn't always true ? but the misses are fractional." James Mottram of Total Film.?Full Review.
"Tom Cruise is in fine form as mysterious tough guy Jack Reacher finally reaches the big screen." Todd McCarthy of The Hollywood Reporter.?Full Review
Do you plan on seeing this movie? Have you seen it already? Leave a review of the film with a comment below.
Source: http://northfield.patch.com/articles/movie-reviews-parker-hansel-and-gretel-witch-hunters-f0dccd6f
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Why I'm Glad My Smartphone Broke
In November, I dropped my iPhone 4 while running and the screen broke. My first instinct was to go and buy the new iPhone 5, but before doing that, I decided to have go without a smartphone for at least a month to find out how much I really depended on it.
I've been a smartphone user for about 5 years. I started with the iPhone 3, grew to the 3GS and later to the 4. I was well on my way to get the 5, when my 4 broke. Looking back, I appreciate that it broke.
Unplugging
In contemporary life with smartphones and computers, we're always connected. During waking hours I was available on Facebook, Twitter, Email, iMessage, my phone, Hipchat, Skype, and in person. Although I disabled push notifications early on, I was still present most places. A few spare minutes would usually result in checking my email, Twitter, and Facebook. I was a little bit everywhere, all the time. But not truly anywhere.
Without the temptation available from my pocket, I feel like I am more present being wherever I am. Now I was certainly no addict, but it's led to a small freedom I encourage you to experience. I've realized that not being constantly plugged in has notable benefits. When I am not on my computer, only my immediate friends and coworkers will be able to reach me by phone. My smartphone helped fill little voids of time with mindless entertainment and shifted me away from the context of whatever I just did and was about to do, silently replacing what I see as mandatory reflection. This context switching I found to play a larger role than I thought. It's been rewarding to indulge more into my own thoughts and reflections, in lieu of attempting to occupy every gap of time with Angry Birds, news, and tweets.
Concerns
I had a few concerns when I went back to my Nokia brick:
No camera. While I've never taken many pictures, I liked my sporadic Instagram posts. When I go traveling, I've always liked to have just a dozen pictures to reflect back on the trip. Perhaps it's time I just borrow a camera when I go traveling. Or just use none at all. I will figure this out when I go traveling in the summer.
No music. Frequently when I walk, I like to have music in my ears to ease the experience. However, I decided not to buy an iPod. Since I got rid of my iPhone, I have definitely missed this, however, most of the time when I really want music, I'm sitting down, able to use my computer. I found that walking to school without music wasn't scary at all. Just as I started running without music a good year before my iPhone broke?it gets you out of your bubble and lets you experience your surroundings. Of course, sometimes it's nice to just leave yourself out. Currently, I have no plans to buy an iPod.
No maps. I used Maps on my iPhone a lot?when visiting friends, traveling, and using public transport. My sense of direction is decent, so I thought getting back into relying on myself and improve these capabilities wouldn't be so terrible. I've found that having no GPS in my pocket requires more planning. Generally it has not been a problem. In foreign countries where I need this the most, I use physical maps anyhow, since data costs are still ridiculous. There's usually nothing wrong with asking a stranger or calling whoever you are visiting anyway.
Unexpected Discoveries
3 months of using an old phone led to some more unexpected discoveries.
I've started calling people more. On an iPhone, texting is extremely convenient. Since I switched to my ancient Nokia phone, I've found myself calling people more simply because it's more accommodating. It's funny how little I called people on my iPhone, and how surprised parts of my generation is when they receive a call. I have rediscovered the core functions of my phone, by indulging in pleasant conversations with people I used to just text, improved arrangements and generally had more fun communicating.
I don't care for my phone anymore. I just drop it into a pocket in my bag and go. This means I carry nothing in my pockets anymore. I have nothing to distract myself, and for odd reasons, that makes me feel free. No longer do I have to check where my phone is before going to sleep. I just don't care for it, since it's not an expensive item anymore that shouldn't get scratches. The fewer things I have to worry about, the better.
My concerns were mostly right, but I can live without these things. The concerns listed in the previous sections were right. I do miss having a camera, I do miss music, and I do miss maps. However, I also found that I can live without these things. That appeals to me, and is a major pro for me. It's handy to have all these things in one device, but for now, the pros outweigh the cons for me.
Not Going Back...For Now
Currently I do not see any convincing reason for me to go back to getting a smartphone. It was funny to observe how natural it feels to have such a powerful device always in your pocket, and how dependent I was on it. How natural it would have felt to pitch in $1000 for a new phone. In many ways, a smartphone has become a mandatory extension of the mind. But I feel it has had no major impact on my life to leave it behind. I have come to deeply enjoy to being completely plugged out when I am not at my computer. I enjoy not always being up to date, and not having one more expensive item to worry about. It is a small temptation in your pocket that can make you lose focus on the people you're around. Only charging my phone every second weekend is an amazing feat too. I challenge you to ditch your smartphone for a month and write about it.
Why I'm glad my iPhone broke | Sirupsen
Simon H?rup Eskildsen is a student, Ruby developer, and competitive programmer. He loves walruses, optimizing, and simplifying things. Follow him on Twitter @sirupsen.
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Source: http://feeds.gawker.com/~r/lifehacker/full/~3/FhFDaEeLhLs/why-im-glad-my-smartphone-broke
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